Review Article
Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
Table 6
Crystallized mannitol based DPI formulations.
| Drug | Method | Key ingredients | PSD (μm) | Device and flow rate (l/min) | % FPF | References |
| SS | ASC | Mannitol and acetonewater (95 : 5) | | Aerolizer and 92 | | [45] |
| SS | ASC | Mannitol and ethanolwater (90 : 10) | | Aerolizer and 92 | | [46] |
| SS | ASC | Mannitol and ethanolacetone (40 : 40) | - | Aerolizer and 92 | | [47] |
| SS | CC | Mannitol 20%, w/v, and deionized water | - | Aerolizer and 92 | | [20] |
| SS | ASC | MannitolPharmatose 100 M (10 : 10) and acetonewater (80 : 20) | | Aerolizer and 92 | | [50] |
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SS: salbutamol sulphate; ASC: antisolvent crystallization; CC: cooling crystallization; and FPF: fine particle fraction.
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