The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP

Figure 8

Effect of various osmolytes on the aggregation kinetics and morphology of hIAPP. Schematic summary of ThT fluorescence assays shows the effect of TMAO (blue), proline (red) and urea (green) on the aggregation kinetics of hIAPP. The corresponding effect on the morphology of the mature fibrils is studied by AFM. All scale bars indicate 1 μm. Adapted and modified from [152, 170] with permission from the Royal Society of Chemistry.