TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway

Figure 4

Protective effects of TAK-875 on pancreatic cells in obese rats and TLR4^KO rats is in synergy with TAK-875. (a) Average weight in each group. (b) The levels of fasting blood glucose. (c) The levels of blood lipid of each group: triglyceride (TG) and low-density lipoprotein (LDL). (d, e) The levels of blood inflammatory cytokines, IL-1 (d) and IL-6 (e). (f) Insulin levels. (g) HOMA-β. (h) The levels of total cholesterol (TCHO). (i) HE staining in pancreatic tissue. (j) The immunofluorescence images of α and β-cells in pancreatic tissues. (k) Apoptosis in pancreatic tissue (the white arrow indicates the apoptotic cells). (l) Expression of TLR4, NF-κB, and GPR40 in pancreatic tissue. ^a vs. NC group, ^b vs. HFD group, ^c vs. HFD+TAK-875 group, ^d vs. TLR4^KO group, and ^e vs. TLR4^KO+HFD group.

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