Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population
Table 3
Genetic model analyses of the association between the SNPs and DKD with adjustment for age and gender.
Genetic models
Genotype
DM
DKD
Without adjustment
With adjustment¶
OR (95% CI)
OR (95% CI)
rs7120118
Additive
CC
161 (46.5%)
168 (56.0%)
1#
1#
TC
160 (46.2%)
120 (40.0%)
0.719 (0.522-0.990)
.043
0.711 (0.514-0.984)
.040
TT
25 (7.2%)
12 (4.0%)
Dominant
CC
161 (46.5%)
168 (56.0%)
1#
.017
1#
.015
TC+TT
185 (53.5%)
132 (44.0%)
0.684 (0.501-0.933)
0.677 (0.494-0.928)
Recessive
CC+TC
321 (92.7%)
288 (96.0%)
1#
.123
1#
.130
TT
25 (7.2%)
12 (4.0%)
0.582 (0.292-1.158)
0.585 (0.293-1.171)
rs2230806
Additive
AA
86 (24.9%)
78 (26.0%)
1#
1#
AG
190 (54.9%)
139 (46.3%)
0.807 (0.554-1.175)
.263
0.819 (0.560-1.197)
.302
GG
70 (20.2%)
83 (27.7%)
Dominant
AA
86 (24.9%)
78 (26.0%)
1#
.739
1#
.842
AG+ GG
260 (75.1%)
222 (74%)
0.941 (0.660-1.343)
0.964 (0.674-1.380)
Recessive
AA + AG
276 (79.8%)
217 (72.3%)
1#
.027
1#
.018
GG
70 (20.2%)
83 (27.7%)
1.508 (1.048-2.171)
1.563 (1.081-2.260)
.¶Adjustment for age and gender. #Reference category (odds ratio, 1.0). Abbreviations: CI: confidence interval; DKD: diabetic kidney disease; DM: diabetes mellitus; ORs: odds ratios.
