Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population
Table 2
Hazard ratios for the incidence of T2DM according to the four phenotype groups and quartile of LAP.
T2DM cases
Incidence density
Unadjusted model
Multivariable adjusted model#
HR (95% CI)
values
HR (95% CI)
values
HTGW phenotype
Total
NTNW
8,615
211
3.347
1.000 (ref)
—
1.000 (ref)
—
NTGW
3,454
269
10.812
3.331 (2.781-3.989)
<0.001
3.422 (2.833-4.135)
<0.001
HTNW
1,593
96
8.192
2.493 (1.959-3.174)
<0.001
2.542 (1.994-3.240)
<0.001
HTGW
2,055
291
19.958
6.301 (5.277-7.523)
<0.001
6.249 (5.199-7.511)
<0.001
Men
NTNW
4,322
116
3.700
1.000 (ref)
—
1.000 (ref)
—
NTGW
683
71
14.462
4.015 (2.988-5.394)
<0.001
4.071 (3.014-5.499)
<0.001
HTNW
942
52
7.496
2.037 (1.469-2.825)
<0.001
2.205 (1.584-3.070)
<0.001
HTGW
626
91
20.604
5.733 (4.357-7.544)
<0.001
5.976 (4.493-7.946)
<0.001
Women
NTNW
4,293
95
2.997
1.000 (ref)
—
1.000 (ref)
—
NTGW
2,771
198
9.915
3.410 (2.670-4.356)
<0.001
3.214 (2.504-4.126)
<0.001
HTNW
651
44
9.202
3.171 (2.218-4.533)
<0.001
3.049 (2.127-4.370)
<0.001
HTGW
1,429
200
19.677
6.978 (5.466-8.909)
<0.001
6.299 (4.892-8.111)
<0.001
Quartile of LAP
Total
Q1 ()
3,823
76
2.731
1.000 (ref)
—
1.000 (ref)
—
Q2 (LAP 9.9-20.1)
3,848
87
3.082
1.153 (0.848-1.569)
0.364
1.169 (0.857-1.595)
0.325
Q3 (LAP 20.2-38.4)
3,839
224
7.984
2.972 (2.291-3.856)
<0.001
2.903 (2.226-3.784)
<0.001
Q4 ()
3,837
465
16.949
6.523 (5.118-8.314)
<0.001
6.298 (4.911-8.077)
<0.001
Men
Q1 ()
1,582
39
3.425
1.000 (ref)
—
1.000 (ref)
—
Q2 (LAP 7.7-16.6)
1,581
41
3.593
1.075 (0.693-1.666)
0.747
1.123 (0.719-1.752)
0.610
Q3 (LAP 16.7-34.7)
1,580
69
5.928
1.743 (1.177-2.582)
0.006
1.839 (1.230-2.748)
0.003
Q4 ()
1,583
172
15.096
4.535 (3.203-6.421)
<0.001
4.773 (3.324-6.854)
<0.001
Women
Q1 ()
2,255
35
2.100
1.000 (ref)
—
1.000 (ref)
—
Q2 (LAP 11.8-22.3)
2,255
59
3.550
1.718 (1.131-2.610)
0.011
1.633 (1.073-2.485)
0.022
Q3 (LAP 22.4-40.8)
2,254
150
9.164
4.480 (3.101-6.474)
<0.001
4.150 (2.865-6.013)
<0.001
Q4 ()
2,257
287
17.882
9.058 (6.377-12.867)
<0.001
8.063 (5.645-11.516)
<0.001
Incidence density, per 1000 person-years; NTNW: normal TG level and normal waist; NTGW: normal TG level and central obesity; HTNW: increased TG level and normal WC; HTGW: increased TG level and central obesity. #Adjusted for age, smoking status, drinking status, physical activity, family history of T2DM, family income, and education; adjusted for sex in the total population at the same time. 370 (247 for men and 123 for women) subjects were excluded because of LAP less than 0.
