Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population
Table 4
Interactions between HTGW and other components of metabolic syndrome on the risk of T2DM.
HTGW
MS components
T2DMcases
Incidence density
Unadjusted model
Multivariable adjusted model#
HR (95% CI)
value
HR (95% CI)
value
HTGW
Increased BP
No
No
8,038
234
3.953
1.000 (ref)
—
1.000 (ref)
—
Yes
No
667
77
15.956
4.180 (3.231-5.407)
<0.001
4.013 (3.091-5.210)
<0.001
No
Yes
5,624
342
8.455
2.124 (1.799-2.508)
<0.001
1.970 (1.653-2.348)
<0.001
Yes
Yes
1,388
214
21.937
5.808 (4.825-6.991)
<0.001
5.251 (4.329-6.369)
<0.001
SI (95% CI): 1.117 (0.846-1.475)
SI (95% CI): 1.067 (0.799-1.425)
AP (95% CI): 0.087 (-0.12-0.294)
AP (95% CI): 0.051 (-0.169-0.271)
REEI (95% CI): 0.504 (-0.734-1.742)
REEI (95% CI): 0.268 (-0.907-1.442)
HTGW
Increased FPG
No
No
11,581
296
3.494
1.000 (ref)
—
1.000 (ref)
—
Yes
No
1,362
107
10.815
3.200 (2.565-3.992)
<0.001
3.017 (2.409-3.778)
<0.001
No
Yes
2,081
280
18.770
5.500 (4.671-6.476)
<0.001
5.286 (4.478-6.238)
<0.001
Yes
Yes
693
184
39.258
12.202 (10.15-14.669)
<0.001
11.573 (9.588-13.971)
<0.001
SI (95% CI): 1.672 (1.36-2.056)
SI (95% CI): 1.678 (1.358-2.072)
AP (95% CI): 0.369 (0.252-0.486)
AP (95% CI): 0.369 (0.251-0.488)
REEI (95% CI): 4.502 (2.489-6.516)
REEI (95% CI): 4.271 (2.33-6.212)
HTGW
Reduced HDL-C
No
No
11,031
451
5.632
1.000 (ref)
—
1.000 (ref)
—
Yes
No
1,365
189
19.886
3.858 (3.255-4.573)
<0.001
3.697 (3.108-4.397)
<0.001
No
Yes
2,631
125
6.389
1.058 (0.868-1.290)
0.575
1.117 (0.913-1.366)
0.284
Yes
Yes
690
102
20.092
3.331 (2.686-4.130)
<0.001
3.140 (2.514-3.923)
<0.001
SI (95% CI): 0.799 (0.567-1.126)
SI (95% CI): 0.761 (0.534-1.084)
AP (95% CI): -0.176 (-0.465-0.113)
AP (95% CI): -0.214 (-0.516-0.088)
REEI (95% CI): -0.586 (-1.468-0.296)
REEI (95% CI): -0.673 (-1.528-0.182)
Incidence density, per 1000 person-years; HTGW: increased TG level and central obesity; BP: blood pressure; FPG: fast plasma glucose; HDL-C: high-density lipoprotein cholesterol; MS: metabolic syndrome; SI: synergy index; AP: attributable proportion due to the interaction; RERI: relative excess risk due to the interaction. #Adjusted for age, sex, smoking status, drinking status, physical activity, family history of T2DM, family income, and education.
