Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population

Table 5

Interactions between high LAP and other components of metabolic syndrome on the risk of T2DM.

High LAP	MS components		T2DM cases	Incidence density	Unadjusted model		Multivariable adjusted model^#
					HR (95% CI)	value	HR (95% CI)	value
High LAP	Increased BP
No	No	6,210	123	2.684	1.000 (ref)	—	1.000 (ref)	—
Yes	No	2,251	180	10.961	4.195 (3.335-5.276)	<0.001	4.169 (3.306-5.257)	<0.001
No	Yes	3,485	132	5.252	1.931 (1.510-2.468)	<0.001	1.799 (1.395-2.320)	<0.001
Yes	Yes	3,401	417	17.259	6.651 (5.440-8.133)	<0.001	6.15 (4.987-7.584)	<0.001
					SI (95% CI): 1.370 (1.110-1.690)		SI (95% CI): 1.298 (1.045-1.611)
					AP (95% CI): 0.229 (0.099-0.360)		AP (95% CI): 0.192 (0.052-0.332)
					REEI (95% CI): 1.526 (0.577-2.475)		REEI (95% CI): 1.182 (0.259-2.105)
High LAP	Increased FPG
No	No	8,497	134	2.152	1.000 (ref)	—	1.000 (ref)	—
Yes	No	4,105	257	8.601	4.088 (3.318-5.038)	<0.001	4.015 (3.25-4.96)	<0.001
No	Yes	1,198	121	13.911	6.464 (5.055-8.265)	<0.001	6.33 (4.936-8.118)	<0.001
Yes	Yes	1,547	340	31.760	15.911 (13.026-19.434)	<0.001	15.198 (12.393-18.638)	<0.001
					SI (95% CI): 1.744 (1.445-2.104)		SI (95% CI): 1.701 (1.406-2.059)
					AP (95% CI): 0.400 (0.298-0.502)		AP (95% CI): 0.385 (0.279-0.491)
					REEI (95% CI): 6.359 (4.063-8.655)		REEI (95% CI): 5.853 (3.620-8.086)
High LAP	Reduced HDL-C
No	No	8,101	215	3.640	1.000 (ref)	—	1.000 (ref)	—
Yes	No	3,961	412	14.654	4.303 (3.649-5.075)	<0.001	4.203 (3.554-4.970)	0.706
No	Yes	1,594	40	3.360	0.869 (0.620-1.218)	0.415	0.937 (0.666-1.316)	<0.001
Yes	Yes	1,691	185	14.837	3.832 (3.147-4.665)	<0.001	3.735 (3.051-4.573)	<0.001
					SI (95% CI): 0.893 (0.693-1.150)		SI (95% CI): 0.871 (0.672-1.129)
					AP (95% CI): -0.089 (-0.296-0.118)		AP (95% CI): -0.108 (-0.322-0.106)
					REEI (95% CI): -0.341 (-1.105-0.424)		REEI (95% CI): -0.404 (-1.171-0.363)

Incidence density, per 1000 person-years; HTGW: increased TG level and central obesity; BP: blood pressure; FPG: fast plasma glucose; HDL-C: high-density lipoprotein cholesterol; MS: metabolic syndrome; SI: synergy index; AP: attributable proportion due to the interaction; RERI: relative excess risk due to the interaction. ^#Adjusted for age, sex, smoking status, drinking status, physical activity, family history of T2DM, family income, and education. Grouped by optimal cutoff value () calculating through ROC curve analysis, 370 (247 for men and 123 for women) subjects were excluded because of LAP less than 0.