Serum Legumain Is Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes

Table 2

Logistic regression analysis for PAD.

	Univariable		Multivariable
	OR (95% CI)	value	aOR (95% CI)	value
Legumain	1.02 (1.01-1.03)	0.001	1.03 (1.01-1.06)	0.006
Age	1.08 (1.06-1.10)	<0.001	1.12 (1.07-1.17)	<0.001
Male	1.52 (1.05-2.21)	0.027	1.74 (0.71-4.29)	0.224
Duration of diabetes	1.08 (1.04-1.11)	<0.001	1.09 (1.02-1.16)	0.007
Hypertension	2.01 (1.39-2.91)	<0.001	2.77 (1.40-5.60)	0.004
LDL-C	0.97 (0.81-1.17)	0.748	1.21 (0.86-1.73)	0.275
hs-CRP	1.06 (1.02-1.12)	0.009	0.96 (0.86-1.07)	0.484
HCY	1.08 (1.02-1.14)	0.007	0.95 (0.85-1.06)	0.352
HOMA-IR	1.01 (1.00-1.02)	0.005	1.02 (1.01-1.04)	0.009
eGFR	0.99 (0.99-1.00)	0.004	1.01 (1.00-1.02)	0.208
Smoking history	1.93 (1.32-2.83)	0.001	3.53 (1.40-9.34)	0.009
DR	1.84 (1.20-2.86)	0.006	1.02 (0.51-2.01)	0.954
Carotid plaque	4.01 (2.69-6.06)	<0.001	1.29 (0.63-2.65)	0.487
BMI	0.96 (0.90-1.01)	0.113
WC	1.01 (0.99-1.03)	0.334
SBP	1.02 (1.01-1.03)	0.001
DPN	1.42 (0.96-2.10)	0.082
DN	1.39 (0.98-1.97)	0.063
Stroke	5.20 (1.83-18.57)	0.004
FBG	1.03 (0.98-1.09)	0.242
2hPBG	1.00 (0.96-1.04)	0.965
HbA1C	1.00 (0.93-1.08)	0.945
TG	1.04 (0.92-1.17)	0.513
TC	0.98 (0.84-1.15)	0.831
HDL-C	1.21 (0.80-1.88)	0.362
UA	1.00 (1.00-1.00)	0.292
Insulin	1.48 (0.94-2.34)	0.089
OADs	1.35 (0.93-1.97)	0.115
Statins	4.53 (1.86-12.67)	0.002
Aspirin	3.63 (1.53-9.55)	0.005

Abbreviation as in Table 1.