Current Studies on Molecular Mechanisms of Insulin Resistance

Table 3

Association with gene polymorphism of IRS with insulin resistance or DM in various populations.

Gene polymorphism	Results	Population	Reference
IRS1Arg972Gly	Increased insulin resistance	Obese Caucasian children	[64]
IRS1 Gly972Arg and Ala512Pro	Not associated with T2D	Sistan and Baluchistan population of Iran	[69]
IRS1 Gly972Arg	Not associate with prediabetes	Northern Vietnamese women	[84]
IRS1 Gly972Arg	Contributing risk factor for the development of T2D	Egyptian patients with chronic hepatitis C virus infection and T2D	[65]
IRS1Gly972Arg	Involved with GDM	Saudi, Iraq, Greek, and Egyptian population	[72–75]
IRS1Gly972Arg	Associate with risk of obesity	Obese Polish pregnant women	[81]
IRS1Gly972Arg	Associated with T2D	Kurdish ethnic, Saudi, and Pakistani population	[66–68, 85]
IRS1Gly972Arg	Correlated with newly diagnosed diabetic patients	Iranian	[86]
IRS1Gly972Arg and Ala513Pro	Not associated with T2D	Arab or Berber and Asian Indian populations	[70, 71]
IRS2Gly1057Asp	Not associated with T2D	Arab or Berber and Tunisian population	[70, 87]
IRS2 Gly1057Asp	Associate with T2D only in female	Bangladeshi population	[80]
IRS2 Gly1057Asp	No association with obesity	Obese Polish pregnant women	[81]
IRS2Gly1057Asp	Associated with T2D	Kurdish ethnic	[66]
IRS2 1057G/D	Associated with DM	Iranian	[77]
IRS2Asp1057Gly	Increased insulin resistance	Obese Caucasian children	[64]
IRS2Gly1057Asp	Associated with GDM	Turkish women	[79]
IRS2Gly1057Asp	Related with coronary artery disease	Taiwanese	[88]
IRS2Gly1057Asp	Increases susceptibility to T2D	Asian Indian	[89]
IRS4 Val1100Ile, His879Asp, His879Tyr, Ser439Cys, Arg411Glu, and Leu34Phe	Associated with body mass index in patient with schizophrenia	Caucasians	[82]
IRS4Leu34Phe, Arg411Gly, Gly584Cys, His879Asp, and Lys883Thr	Not associated with T2D or insulin resistance	Danish Caucasians	[83]