Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery
Table 1
Metabolic response rate distributions.
RYGB
SG
Control
#
9
7
8
Age (years)
49 [47, 53]
49 [47, 51]
49 [43, 61]
Sex (female)
9
3
4
Preoperative
BMI (kg/m2)
41.9 [41.8, 45.5]§
40.5 [39.6, 44.8]§
25.4 [24.6, 26.2]
TBW (kg)
120.5 [117.2, 127.6]§
129.6 [111.8, 143.2]§
73.7 [69.4, 78.1]
LBM (kg)
64.4 [57.4, 65.7]§
79.3 [57.4, 84.9]§
48.9 [41.0, 57.9]
Glucose
(mmol/L)
7.1 [6.7, 8.2]§
6.5 [6.2, 7.8]§
5.3 [4.9, 5.7]
(mmol/L)
13.5 [13.0, 15.1]§
14.4 [12.2, 14.9]§
9.8 [8.7, 11.1]
(min)
90.0 [71.3, 120.0]§
60.0 [60.0, 82.5]
45.0 [45.0, 60.0]
AUC (mmol/L·min)
24.2 [23.5, 25.7]§
23.2 [22.0, 26.9]§
15.9 [15.1, 17.8]
Insulin
(mmol/L)
74.0 [65.6, 107.5]§
117.5 [76.3, 155.5]§
33.5 [28.5, 37.8]
(pmol/L)
309.0 [183.0, 408.0]
351.0 [287.5, 554.8]
377.0 [274.5, 489.0]
(min)
90.0 [56.3, 150.0]
60.0 [37.5, 108.8]
45.0 [30.0, 67.5]
AUC (pmol/L·min)
5.1 [3.1, 6.6]
5.3 [4.9, 8.1]
3.8 [2.5, 5.0]
C-peptide
(mmol/L)
1091.5 [1011.0, 1468.5]§
1229.5 [953.8, 1602.8]§
480.8 [417.3, 517.0]
(pmol/L)
2606.0 [1835.0, 3506.3]
2515.0 [2216.3, 3043.8]
2271.0 [2047.0, 2775.0]
(min)
120.0 [112.5, 150.0]§
120.0 [75.0, 120.0]§
67.5 [52.5, 90.0]
AUC (pmol/L·min)
5396.0 [3726.2, 6360.9]
4871.4 [4651.2, 5901.8]
4079.4 [3368.6, 4528.8]
Postoperative
BMI (kg/m2)
38.1 [35.7, 39.5]§
34.6 [33.4, 38.2]§
TBW (kg)
107.5 [99.0, 111.7]§
109.9 [102.4, 122.5]§
LBM (kg)
59.2 [52.5, 60.9]§
70.0 [57.6, 77.1]§
Glucose
(mmol/L)
5.0 [4.9, 5.6]
5.3 [4.7, 5.5]
(mmol/L)
13.1 [12.3, 13.3]§
11.1 [11.0, 11.7]§
(min)
60.0 [45.0, 60.0]
45.0 [45.0, 60.0]
AUC (mmol/L·min)
19.0 [17.9, 22.0]
17.3 [16.7, 19.3]
Insulin
(mmol/L)
36.0 [28.1, 52.5]
57.5 [38.8, 83.1]§
(pmol/L)
424.0 [290.3, 653.5]
497.0 [341.3, 1140.8]
(min)
45.0 [30.0, 60.0]
30.0 [20.0, 56.3]
AUC (pmol/L·min)
3.3 [2.8, 4.7]
4.1 [3.2, 9.2]
C-peptide
(mmol/L)
703.5 [674.0, 864.5]§
968.5 [585.3, 1064.0]§
(pmol/L)
3378.0 [1962.3, 3714.5]
2785.0 [2408.5, 4148.0]
(min)
60.0 [45.0, 63.8]
45.0 [33.8, 56.3]§
AUC (pmol/L·min)
4919.3 [3530.5, 5382.5]
4501.7 [3881.3, 6727.9]
Values are reported as median [25th, 75th] percentile range. Significant compared to preoperative. §Significant compared to healthy control. RYGB: Roux-en Y gastric bypass; SG: sleeve gastrectomy.