Identification and Validation of the Pyroptosis-Related Hub Gene Signature and the Associated Regulation Axis in Diabetic Keratopathy

Figure 5

Protein-protein interaction (PPI) network integration and identification of hub genes. (a) Visualization of DEPRGs obtained from STRING database with interaction . (b) The distribution of DEPRGs that are predicted by Molecular Complex Detection. The red and blue colors represent higher and lower expression, respectively. (c) Identification of key module 1 and module 2 in the PPI network by Molecular Complex Detection. (d) The correlation analysis between the different hub genes. The red and blue colors represent positive and negative correlations, respectively. (e) The functional similarity of the hub genes using the friends analysis. Nfkb1 showed the strongest correlation with other genes. (f) Hub genes screened by 10 algorithms from cytoHubba. (g) The functional similarity of the five hub genes using the friends analysis. DEPRGs: differentially expressed pyroptosis-related genes; MCC: Maximal Clique Centrality; DMNC: Density of Maximum Neighborhood Component; MNC: Maximum Neighborhood Component; EPC: Edge Percolated Component.

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