Tailoring Type II Diabetes Treatment: Investigating the Effect of 5-HTT Polymorphisms on HbA1c Levels after Metformin Initiation

Table 1

Participant characteristics—split between 5-HTTLPR and 5-HTT VNTR genotypes ().

Characteristics	5-HTTLPR				5-HTT VNTR
Genotype breakdown	LL ()	LS ()	SS ()	Sig	STin 2.12/- ()	STin 2.10/- ()	Sig
Total number of participants (%)
Male	31 (67.4%)	35 (50%)	22 (53.7%)		75 (59.5%)	13 (41.9%)
Female	15 (32.6%)	35 (50%)	19 (46.3%)		51 (40.5%)	18 (58.1%)
Age in years ()				0.63			0.67
Baseline HbA1c (%)				0.42			0.59
HbA1c value 6 months (%)				0.85			0.06
Baseline BMI				0.68			0.99
Baseline blood pressure (mmHg)
Systolic				0.25			0.15
Diastolic				0.67			0.32
Baseline lipid levels (mmol/L)
Total cholesterol				0.52			0.23
HDL cholesterol				0.49			0.51
Triglycerides				0.27			0.81
LDL cholesterol				0.40			0.96
Serum creatinine levels (mmol/L)				0.95			0.59

Sig: significance; HbA1c: hemoglobin A1c; HDL: high-density lipoprotein; LDL: low-density lipoprotein; 5-HTTLPR: serotonin transporter linked promoter region; 5-HTT VNTR: serotonin transporter variable number tandem repeat in the second intron.