Research Article
Tailoring Type II Diabetes Treatment: Investigating the Effect of 5-HTT Polymorphisms on HbA1c Levels after Metformin Initiation
Table 1
Participant characteristics—split between 5-HTTLPR and 5-HTT VNTR genotypes (
).
| Characteristics | 5-HTTLPR | 5-HTT VNTR | Genotype breakdown | LL () | LS () | SS () | Sig | STin 2.12/- () | STin 2.10/- () | Sig |
| Total number of participants (%) | | | | | | | | Male | 31 (67.4%) | 35 (50%) | 22 (53.7%) | | 75 (59.5%) | 13 (41.9%) | | Female | 15 (32.6%) | 35 (50%) | 19 (46.3%) | | 51 (40.5%) | 18 (58.1%) | | Age in years () | | | | 0.63 | | | 0.67 | Baseline HbA1c (%) | | | | 0.42 | | | 0.59 | HbA1c value 6 months (%) | | | | 0.85 | | | 0.06 | Baseline BMI | | | | 0.68 | | | 0.99 | Baseline blood pressure (mmHg) | | | | | | | | Systolic | | | | 0.25 | | | 0.15 | Diastolic | | | | 0.67 | | | 0.32 | Baseline lipid levels (mmol/L) | | | | | | | | Total cholesterol | | | | 0.52 | | | 0.23 | HDL cholesterol | | | | 0.49 | | | 0.51 | Triglycerides | | | | 0.27 | | | 0.81 | LDL cholesterol | | | | 0.40 | | | 0.96 | Serum creatinine levels (mmol/L) | | | | 0.95 | | | 0.59 |
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Sig: significance; HbA1c: hemoglobin A1c; HDL: high-density lipoprotein; LDL: low-density lipoprotein; 5-HTTLPR: serotonin transporter linked promoter region; 5-HTT VNTR: serotonin transporter variable number tandem repeat in the second intron.
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