Research Article
Tailoring Type II Diabetes Treatment: Investigating the Effect of 5-HTT Polymorphisms on HbA1c Levels after Metformin Initiation
Table 2
Multiple linear regression for the difference in HbA1c between baseline and six months.
| Baseline predictors | Standard analysis () | Imputed analysis () | Complete case () | | 95.0% CI for | value | | 95.0% CI for | value | | 95.0% CI for | value |
| Age | -0.01 | -0.03–0.01 | 0.12 | -0.004 | -0.02–0.01 | 0.44 | -0.01 | -0.03–0.01 | 0.12 | Sex | -0.05 | -0.28–0.18 | 0.68 | -0.01 | -0.22–0.2 | 0.93 | -0.05 | -0.28–0.18 | 0.68 | 5-HTTLPR (LL) | | | | | | | | | | LS | -0.01 | -0.26–0.24 | 0.94 | -0.03 | -0.25–0.2 | 0.81 | -0.01 | -0.26–0.24 | 0.94 | SS | -0.05 | -0.34–0.24 | 0.74 | -0.01 | -0.26–0.25 | 0.97 | -0.05 | -0.34–0.24 | 0.74 | 5-HTT VNTR (12/-) | | | | | | | | | | 10/- | 0.15 | -0.13–0.43 | 0.29 | -0.03 | -0.27–0.21 | 0.79 | 0.15 | -0.13–0.43 | 0.29 | HbA1c at baseline | 0.66 | 0.53–0.79 | 0.01 | 0.89 | 0.82–0.97 | <0.001 | 0.66 | 0.53–0.79 | <0.001 | BMI (up to baseline) | 0.004 | -0.02–0.03 | 0.71 | 0.01 | -0.02–0.04 | 0.34 | 0.004 | -0.02–0.03 | 0.71 | Systolic blood pressure (up to baseline) | -0.004 | -0.01–0.01 | 0.24 | -0.001 | -0.01–0.01 | 0.95 | -0.004 | -0.01–0.01 | 0.24 | Triglycerides (up to baseline) | -0.07 | -0.17–0.04 | 0.20 | -0.08 | -0.19–0.02 | 0.12 | -0.07 | -0.17–0.04 | 0.20 | LDL (up to baseline) | 0.08 | -0.05–0.2 | 0.22 | 0.003 | -0.11–0.11 | 0.96 | 0.08 | -0.05–0.2 | 0.22 | Serum creatinine (up to baseline) | -0.001 | -0.01–0.01 | 0.97 | 0.001 | -0.01–0.01 | 0.70 | -0.001 | -0.01–0.01 | 0.97 |
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HbA1c: hemoglobin A1c; HDL: high-density lipoprotein; LDL: low-density lipoprotein; 5-HTTLPR: serotonin transporter linked promoter region; 5-HTT VNTR: serotonin transporter variable number tandem repeat in the second intron; ; . |