Tailoring Type II Diabetes Treatment: Investigating the Effect of 5-HTT Polymorphisms on HbA1c Levels after Metformin Initiation

Table 2

Multiple linear regression for the difference in HbA1c between baseline and six months.

Baseline predictors	Standard analysis ()			Imputed analysis ()			Complete case ()
		95.0% CI for	value		95.0% CI for	value		95.0% CI for	value
Age	-0.01	-0.03–0.01	0.12	-0.004	-0.02–0.01	0.44	-0.01	-0.03–0.01	0.12
Sex	-0.05	-0.28–0.18	0.68	-0.01	-0.22–0.2	0.93	-0.05	-0.28–0.18	0.68
5-HTTLPR (LL)
LS	-0.01	-0.26–0.24	0.94	-0.03	-0.25–0.2	0.81	-0.01	-0.26–0.24	0.94
SS	-0.05	-0.34–0.24	0.74	-0.01	-0.26–0.25	0.97	-0.05	-0.34–0.24	0.74
5-HTT VNTR (12/-)
10/-	0.15	-0.13–0.43	0.29	-0.03	-0.27–0.21	0.79	0.15	-0.13–0.43	0.29
HbA1c at baseline	0.66	0.53–0.79	0.01	0.89	0.82–0.97	<0.001	0.66	0.53–0.79	<0.001
BMI (up to baseline)	0.004	-0.02–0.03	0.71	0.01	-0.02–0.04	0.34	0.004	-0.02–0.03	0.71
Systolic blood pressure (up to baseline)	-0.004	-0.01–0.01	0.24	-0.001	-0.01–0.01	0.95	-0.004	-0.01–0.01	0.24
Triglycerides (up to baseline)	-0.07	-0.17–0.04	0.20	-0.08	-0.19–0.02	0.12	-0.07	-0.17–0.04	0.20
LDL (up to baseline)	0.08	-0.05–0.2	0.22	0.003	-0.11–0.11	0.96	0.08	-0.05–0.2	0.22
Serum creatinine (up to baseline)	-0.001	-0.01–0.01	0.97	0.001	-0.01–0.01	0.70	-0.001	-0.01–0.01	0.97

HbA1c: hemoglobin A1c; HDL: high-density lipoprotein; LDL: low-density lipoprotein; 5-HTTLPR: serotonin transporter linked promoter region; 5-HTT VNTR: serotonin transporter variable number tandem repeat in the second intron; ; .