Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis

Figure 1

The administration of JPGS showed a therapeutic effect in mice with DN. The administration of JPGS controlled body weight, fasting blood glucose levels, and kidney function in DN mice. The changes in (a) body weight and (b) fasting blood glucose levels for each group are shown in the curve graphs. After JPGS treatment, there were improvements in kidney function, as seen in the changes in (c) 24 h UTP, (d) Cr, and (e) BUN. Kidney tissue samples stained with (f) HE and (g) PAS were also analyzed. JPGS treatment resulted in a reduction of proinflammatory cytokines (h) IL-1β, (i) IL-6, and (j) TNF-α in the kidney. Control, model, IRB, JPGS-L, JPGS-M, and JPGS-H ( per group) groups. Data are presented as . ^## vs. control group. and vs. model group.

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