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Instrument | NOVA View | AKLIDES | EUROPattern | Image Navigator | Helios | ZENIT G Sight |
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Manufacturer | INOVA diagnostics | Medipan | Euroimmun | Immunoconcepts | Aesku | Menarini |
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LIMS connection (software) | Yes (QUANTA Link) | Yes (system independent, standard XML interface) | Yes (EUROLabOffice) | Yes (direct) Optional: lab traffic control | Yes (direct) Optional: Aesku.Lab middleware | Yes (ZenIT) |
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Slide identification via barcode | Yes by handheld scanner | Yes by handheld scanner | Yes by integrated scanner | Yes | Yes by integrated scanner | Yes by integrated scanner |
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Loading capacity | 5 slides (up to 60 wells) | 5 slides (up to 60 wells) | 50 slides (up to 500 wells) | 4 slides (up to 84 wells) | 20 slides (up to 240 wells) | 5 slides (up to 70 wells) |
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Image acquisition speed | ~45 s/well for 3 images | ~40 s/well | <20 s/well | ~25 s/well for 4 images | 10 s/picture Customizable from 1 to 10 images | >60 s/well number of pictures: 5 (small scan), 50 (medium scan), or 220 (full scan) |
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100% QC for substrate and process integrity/counterstaining | Yes/DAPI | Yes/DAPI | Yes/Propidium iodide | None/None | None/None | None/None |
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Automatic pos./neg. discrimination incl. presorting of images | Yes | Yes | Yes | Yes | Yes | Yes |
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Batchwise verification of negative samples | Yes | Yes | Yes | Yes | Yes | Yes |
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Automatic pattern recognition | Yes | Yes | Yes | No | No | Yes |
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Pattern Analysis method | Pattern recognition by mathematical algorithm | Pattern recognition by mathematical algorithm | Pattern recognition by mathematical algorithm | No pattern matching capabilities | No pattern matching capabilities | Pattern recognition by mathematical algorithm |
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Number of recognizable ANA staining pattern list out | 6 Homogeneous Speckled Centromere Nucleolar Nuclear dot Cytoplasm Negative Positive unrecognized | 10 Homogeneous Speckled Centromere Nucleolar Nuclear dot Cytoplasm Negative Positive unrecognized
| 8 Homogeneous Speckled Centromere Nucleolar Nuclear dot Cytoplasm Negative Nuclear rim Mixed pattern mitotic | None | None | 5 Homogeneous Speckled Centromere Nucleolar Cytoplasm Negative |
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Analysis of mixed staining pattern | Limited (homogeneous/ nucleolar) | Yes | Yes | No | No | No |
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Merged results per patient (different dilutions) | Yes | Yes | Yes | Yes | Yes | Yes |
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Final result validation possible while system processes remaining samples | Yes | No | Yes | Yes | Yes | No |
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Instrument calibration to minimize variability | Yes | Yes | Yes | Yes | Yes | No |
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Integration with slide processing in 1 instrument | No | No | No | No | Yes | No |
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