Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus

Table 4

Associations between specific autoantibodies and clinical manifestations of SLE [patient number (%)].

Anti-dsDNA

Anti-Sm

Anti-RNP

Anti-SSA

Anti-SSB

Anti-rRNP

APL

Positive

𝑃

Positive

𝑃

Positive

𝑃

Positive

𝑃

Positive

𝑃

Positive

𝑃

Positive

𝑃

Patients number

699; (100)

350; (100)

189; (100)

497; (100)

224; (100)

255; (100)

414; (100)

Malar rash

315; (45.06)

0.061

201; (57.43)

<0.001*

91; (48.15)

0.956

241; (48.49)

0.785

105; (46.88)

0.732

151; (59.22)

0.004*

187; (45.17)

0.275

Discoid lesions

31; (4.43)

0.099

22; (6.29)

0.546

13; (6.88)

0.426

25; (5.03)

0.522

11; (4.91)

0.631

13; (5.10)

0.855

20; (4.83)

0.540

Photosensitivity

150; (21.46)

0.008*

95; (27.14)

0.311

47; (24.87)

0.965

132; (26.56)

0.358

67; (29.91)

0.073

69; (27.06)

0.752

96; (23.19)

0.509

Oral ulcerations

151; (21.6)

0.671

87; (24.86)

0.181

42; (22.22)

0.980

108; (21.73)

0.797

48; (21.43)

0.784

48; (18.82)

0.395

74; (17.87)

0.035*

Arthritis

399; (57.08)

0.095

193; (55.14)

0.796

106; (56.08)

0.650

268; (53.92)

0.762

119; (53.13)

0.658

146; (57.25)

0.765

236; (57.00)

0.289

Serositis

119; (17.02)

0.584

55; (15.71)

0.705

31; (16.40)

0.999

89; (17.91)

0.298

46; (20.54)

0.077

35; (13.73)

0.428

61; (14.73)

0.996

Nephropathy

355; (50.79)

0.030*

155; (44.29)

0.196

91; (48.15)

0.837

216; (43.46)

0.042*

102; (45.54)

0.547

120; (47.06)

0.817

191; (46.14)

0.848

Hematological involvement

403; (57.65)

0.321

196; (56.00)

0.957

108; (57.14)

0.769

278; (55.94)

0.920

141; (62.95)

0.030*

137; (53.73)

0.542

273; (65.94)

<0.001*

Neurological involvement

26; (3.72)

0.102

18; (5.14)

0.743

12; (6.35)

0.296

21; (4.23)

0.493

13; (5.80)

0.457

16; (6.27)

0.335

32; (7.73)

0.061

ILD

29/675^$; (4.30)

0.941

18/326^$; (5.52)

0.214

11/181^$; (6.08)

0.201

21/481^$; (4.37)

0.884

12/209^$; (5.74)

0.259

12/250^$; (4.80)

0.940

29/398^$; (7.29)

<0.001*

PAH

24/661^$; (3.63)

0.747

16/322^$; (4.97)

0.242

12/180^$; (6.67)

0.037*

28/469^$ (5.97)

0.005*

11/205^$; (5.37)

0.224

5/237^$; (2.11)

0.151

15/387^$; (3.88)

0.714

𝑃: 𝑃 value; Anti-dsDNA: Anti-double stranded DNA antibody; Anti-Sm: Anti-Sm antibody; Anti-SSA: Anti-SSA antibody; Anti-SSB: Anti-SSB antibody; Anti-RNP: Anti-u1 small-nuclear RNA-protein antibody; Anti-rRNP: Anti-ribosomal RNA-protein antibody; APL: Anti-phospholipid antibody; PAH: pulmonary arterial hypertension; ILD: interstitial lung disease.
$Actually detected number of patients.
^∗𝑃<0.05.