Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy

Figure 2

A model for HMGB1 involvement in resistance to mAb-based immunotherapy. hCD31 mAb-driven hypoxia promotes in NB cells expression of HMGB1 that induces by itself EMT, thus mimicking the effects of hypoxia and serving as an amplification loop. All of these mechanisms in combination account for the refractoriness of NB tumors to TDEC targeting with hCD31 mAb.