Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease

Figure 1

Interaction of DC with different leukocytes in the cutaneous leishmaniasis context. (a) shows the interaction among NK and infected DCs that leads to host immune protection and parasite killing through IFN-γ production during L. amazonensis [73] or L. major [74] infection. (b) shows the outcome induced by the increased production of IL-10 after the interaction between infected neutrophils (NΦ) with L. major [75] or L. mexicana [76] and DCs, leading to parasite persistence.