Gq-Coupled Receptors in Autoimmunity

Figure 1

Signaling pathways demonstrating the link between Gq-coupled receptors and induction of autoimmunity. The figure shows the major signaling pathways that are believed to regulate the extracellular signals transduce into lymphocytes, which include the classic PLC-β/PKC pathway (left) and inhibition of the PI3K-Akt pathway to maintain normal immune tolerance (right) while Gq can also facilitate the activation of the ERK-MAPK pathway, regulating the differentiation of lymphocytes and controlling the expression of cytokines (middle).