Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity

Table 2

Gene/protein expression changes induced by hypoxia in murine DCs.

Gene(s)/protein(s)	Changes in gene/protein expression	Gene/protein function	HIF dependency	References
cd80, cd86	Unaffected in differentiated BmDCs after 24 h of hypoxia; ↑ after hypoxia + LPS; ↑ after hypoxic differentiation of BmDCs	Costimulatory molecules	Yes; No	[41]; [42]
nos2	↑ after hypoxia + LPS	ROS production	Yes	[43]
IFNα4, IFNα12	↑ after hypoxia + LPS	Type I interferon	Most likely indirect	[44]
IFN-β	↑ after hypoxia + LPS	Type I interferon	Most likely indirect	[44]
IL-22	↑ after hypoxic differentiation of BmDCs	Inflammatory cytokine	Yes	[42]
CCR7	↑ after hypoxic differentiation of BmDCs	Chemokine receptor	Yes	[42]
id2	↑ after hypoxic differentiation of pDCs	Inhibits pDC lineage determination	Yes	[45]