Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes

Figure 1

Telomere length in sorted cells and PBMCs. Box and whisker plots display interquartile range, median values, and maximum and minimum values. Telomere length is expressed as basepairs as described earlier [19]. (a) Telomere length in B cells, CD4+, CD8+CD28+, and CD8+CD28− T cells, and PBMCs at base visit and 18 month visit. (b) Telomere length of the base visit and that of 18-month visit from the same cell type of the same individual are highly correlated. The graph includes telomere length from PBMC, CD4+, CD8+CD28+, and CD8+CD28− T cells and B cells from 39 subjects. (c) Telomere length change from base visit to 18 months is negatively correlated with telomere length at base visit. (d) Telomere length change from base visit to 18 months in total PBMC, CD4+, CD8+CD28+, and CD8+CD28− T cells and B cells. for each cell type.

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