| Gene sites | Subgroup | Study number | Number of case/control | Heterogeneity (I2, p) | OR (95% CI), p | Grading |
| IL-18 -607 C/A | | | | | | |
| Allele | Overall | 12 | 6,838/5,816 | 86, <0.00001 | 0.76 (0.61, 0.93), 0.01 | Weak | Caucasian | 5 | 2,506/1,900 | 91, <0.00001 | 0.72 (0.46, 1.12) | Nonsignificant | Asian | 5 | 3,926/3,068 | 86, <0.0001 | 0.73 (0.52, 1.02) | Nonsignificant |
| Recessive | Overall | 12 | 3,419/2,908 | 80, <0.00001 | 0.73 (0.50, 1.06) | Nonsignificant | Caucasian | 5 | 1,253/950 | 86, <0.0001 | 0.73 (0.36, 1.50) | Nonsignificant | Asian | 5 | 1,963/1,534 | 79, 0.0006 | 0.68 (0.37, 1.24) | Nonsignificant |
| Dominant | Overall | 12 | 3,419/2,908 | 81, <0.00001 | 0.67 (0.50, 0.90), 0.008 | Weak | Caucasian | 5 | 1,253/950 | 86, <0.00001 | 0.63 (0.37, 1.07) | Nonsignificant | Asian | 5 | 1,963/1,534 | 86, <0.0001 | 0.64 (0.38, 1.07) | Nonsignificant |
| Hemozygote | Overall | 12 | 1,744/1,389 | 84, <0.00001 | 0.57 (0.35, 0.91), 0.02 | Weak | Caucasian | 5 | 657/445 | 89, <0.00001 | 0.55 (0.23, 1.34) | Nonsignificant | Asian | 5 | 1,003/781 | 86, <0.00001 | 0.53 (0.24, 1.14) | Nonsignificant |
| Heterozygote | Overall | 12 | 2,658/2,271 | 77, <0.00001 | 0.71 (0.54, 0.93), 0.01 | Weak | Caucasian | 5 | 1,070/799 | 78, 0.001 | 0.68 (0.43, 1.06) | Nonsignificant | Asian | 5 | 1,408/1,104 | 81, <0.0001 | 0.67 (0.40, 1.14) | Non-significant |
| IL-18 -137 G/C | | | | | | |
| Allele | Overall | 9 | 3,346/3,284 | 88, <0.00001 | 0.74 (0.52, 1.05) | Nonsignificant | Caucasian | 5 | 2,486/1,900 | 93, <0.00001 | 0.68 (0.39, 1.17) | Nonsignificant | Asian | 2 | 454/536 | 0, 0.58 | 0.59 (0.40, 0.88), 0.01 | Weak |
| Recessive | Overall | 9 | 1,673/1,642 | 83, <0.00001 | 0.70 (0.33, 1.51) | Nonsignificant | Caucasian | 5 | 1,243/950 | 91, <0.00001 | 0.57 (0.20, 1.61) | Nonsignificant | Asian | 2 | 227/268 | 0, 0.33 | 0.48 (0.11, 2.07) | Nonsignificant |
| Dominant | Overall | 9 | 1,673/1,642 | 74, 0.0002 | 0.76 (0.56, 1.04) | Nonsignificant | Caucasian | 5 | 1,243/950 | 85, <0.0001 | 0.73 (0.46, 1.18) | Nonsignificant | Asian | 2 | 227/268 | 0, 0.82 | 0.57 (0.37, 0.89), 0.01 | Weak |
| Hemozygote | Overall | 9 | 1,089/1,085 | 83, <0.00001 | 0.67 (0.30, 1.47) | Nonsignificant | Caucasian | 5 | 765/593 | 91, <0.00001 | 0.54 (0.18, 1.59) | Nonsignificant | Asian | 2 | 190/205 | 0, 0.35 | 0.43 (0.10, 1.86) | Nonsignificant |
| Heterozygote | Overall | 9 | 1,553/1,497 | 8, 0.37 | 0.89 (0.76, 1.06) | Nonsignificant | Caucasian | 5 | 1,136/824 | 23, 0.27 | 0.94 (0.75, 1.17) | Nonsignificant | Asian | 2 | 224/260 | 0, 0.95 | 0.60 (0.38, 0.94), 0.03 | Weak |
| IL-18 -920 C/T | | | | | | |
| Allele | Overall | 2 | 3,746/2,182 | 0, 1.00 | 0.85 (0.76, 0.95), 0.004 | Weak | Recessive | Overall | 2 | 1,873/1,091 | 67, 0.08 | 0.29 (0.03, 3.36) | Nonsignificant | Dominant | Overall | 2 | 1,873/1,091 | 0, 0.85 | 0.90 (0.76, 1.08) | Nonsignificant | Hemozygote | Overall | 2 | 1,038/615 | 66, 0.08 | 0.30 (0.03, 3.35) | Nonsignificant | Heterozygote | Overall | 2 | 1,572/837 | 0, 0.84 | 1.01 (0.84, 1.21) | Nonsignificant |
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