Upper Airway Epithelial Tissue Transcriptome Analysis Reveals Immune Signatures Associated with COVID-19 Severity in Ghanaians

Figure 2

Gene ontology (GO) pathway analysis of top differentially expressed genes in the study cohort. (a) Dotplot showing top activated and suppressed pathways in SARS-CoV-2-infected Ghanaians. Immune response pathways were activated, while cellular biogenesis-related processes were suppressed. (b) Cnetplot showing protein–protein interaction network analysis for the top DEG genes in the COVID-19-infected cohort. (c) Dotplot showing activated and suppressed pathways in severe compared to mild COVID-19 cohorts. Immune response-related pathways or processes were suppressed in individuals with severe COVID-19. Top enriched pathways are shown p.adjusted <0.05. (d–f) Violin plots compare the expression of selected antiviral gene expressions in male and female SARS-Cov-2-infected Ghanaians.

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