Disturbances in the IgG Antibody Profile in HIV-Exposed Uninfected Infants Associated with Maternal Factors

Figure 3

Influence of ART regimen exposure on the antibody profile of HEU infants. Plasma concentrations of IgG1 (a), IgG2 (b), IgG3 (c), and IgG4 (d) in HEU newborns divided by maternal ART regimen group. Plasma concentrations of IgG1 (e), IgG2 (f), IgG3 (g), IgG4 (h), IgM (i), IgA (j), and IgE (k) in 2- to 3-month-old HEU infants stratified according to the predominant ART regimens. The 0-month-old group comprised (group 1, n = 5; group 2, n = 15; group 3, n = 15; group 4, n = 11); and the 2- to 3-month-old group comprised (group 1, n = 4; group 2, n = 9; group 3, n = 12; group 4, n = 6). Boxes indicate medians and interquartile ranges, with bars indicating percentiles 5 and 95. The sparse data points indicate observations outside these percentiles. Significant differences between groups were assessed using the Kruskal‒Wallis test with Dunn’s post hoc test; , , and . ABA, abacavir; DAR, darunavir; EFA, efavirenz; EMT, emtricitabina; LOP, lopinavir; RIT, ritonavir; TEN, tenofovir; and ART, antirretroviral treatment.