Epigenetics can be defined as the collective modifications in the chemical structure of DNA and histone proteins, without altering the basic DNA nucleotide sequence. This can result in changes in gene expression primarily via regulating chromatin accessibility. Gene expression can also be altered by non-coding RNAs which have been increasingly recognized to be expressed throughout the genome. Understanding epigenetic modifications and the functional implications of individual epigenetic marks has helped to illuminate the complexity of mammalian genomes and has provided important insights into the regulatory role of intergenic and non-protein-coding genomic regions. In addition, genetic-epigenetic interaction, whereby disease-associated genetic variants directly or indirectly influence locus-specific epigenetic modifications, can provide mechanistic implications for disease-associated genetic variants in immune-mediated diseases.

This Special Issue aims to explore various aspects of the role of epigenetics in clinical immunology and autoimmunity. Submissions including original research and review articles are welcome for this Special Issue.

Potential topics include but are not limited to the following:

• Up-to-date research on the underlying molecular events contributing to epigenetic dysregulation, and the various epigenetic mechanisms
• Epigenetic studies in immune cells and the salivary glands and research discussing possible implications for understanding the pathogenesis of this kind of disease
• Potential for using epigenetic marks in disease prediction and personalized medicine
• EpiTOF in immune cell types and potential applications of EpiTOF in medical research
• The role of epigenetics in immune-aging and the relationship to autoimmunity
• Epigenetic interplay within the tumor microenvironment and how epigenetic changes in cancer cells, stromal cells, and immune cells can be exploited for more effective treatment in cancer patients
• The interaction between environmental factors and epigenetics in inducing autoimmunity
• Development and exploration of new models for the clinical management of patients with immune-related diseases
• Exploring new immune regulation mechanisms involved in human disease
• New insights into tumor immunity and transplantation immunity