Journal of Lipids / 2012 / Article / Tab 1 / Review Article
Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer Table 1 Expression levels of PON2 in various tumor tissues and/or cancer cell cultures. Microarray experiment (array express) listings are according to the Gene Atlas Database. Protein and cDNA levels according to [
23 ]. Cell culture expression levels were roughly estimated as relative level comparing to A549, grouped into
low, medium, or
high .
Tissue (cancer) Protein level (fold of normal tissue) cDNA array (fold of normal tissue) Microarray studies Cell culture (expression level in cell line) Kidney 2 2.2 Upregulated in renal carcinoma (E-MTAB-37) Medium (HEK293) Liver 1.7 2.2 Overexpressed (Li et al. [15 ]) High (Huh7/HepG2) Lung 1.3 1 Upregulated in lung adenocarcinoma (E-MEXP-231/E-MTAB-37) Downregulated in small cell lung carcinoma (E-GEOD-4127) High (A549; H661; H1299) Spleen 0.5 n/a Pancreas 1.4 1.6 Upregulated in pancreatic carcinoma (E-MTAB-37) Thymus 11.5 n/a Urinary bladder n/a 4.1 High (HT1367/RT112) Esophagus n/a 0.6 Upregulated in esophageal cancer (E-MTAB-62) Stomach n/a 1 Upregulated in gastric carcinoma (E-GEOD-2685) Ovar n/a 1 Upregulated (E-MTAB-62) Cervix n/a 1 Upregulated (E-MTAB-37/E-MTAB-62) Medium (HeLa) Adrenal gland n/a 1 Downregulated in adrenocortical carcinoma (E-TABM-311) Thyroid gland n/a 1.4 Upregulated (E-GEOD-3467/E-GEOD-3678) Prostate n/a 1.6 Overexpressed (Ribarska, T. et al. [16 ] E-MTAB-62) Testis n/a 1.7 Low (SuSa/GCT27/833K) Uterus/endometrium n/a 2.1 Lymphoid tissue n/a 2.5 Leukemias (various) n/a Upregulated in pediatric ALL (Ross et al. and Kang et al. [17 , 18 ]) Low in AML-like Nalm6/EOL; Jurkat Tcells; PML-like HL60/HCW2; CML-like KCL Medium in blast crisis line K562; CML-like lama; AML-like THP1/MonoMac6/HEL Non-Hodgkin 11.9 n/a Downregulated (E-MTAB-37)