Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease
Table 1
Characteristics of the 51 SNPs studied in the PON gene cluster.
SNP
Gene
Functiona
Minor alleleb
Major allele
MAFc
rs854549
PON1
3′-downstream
A
C
0.337
rs3735590
PON1
3′-UTR
A
G
0.060
rs3917577
PON1
3′-UTR
G
A
0.089
rs854552
PON1
3′-UTR
G
A
0.265
rs3917551
PON1
Intronic
A
G
0.051
rs3917550
PON1
Intronic
A
G
0.137
rs2269829
PON1
Intronic
G
A
0.278
rs3917542
PON1
Intronic
A
G
0.227
rs3917538
PON1
Intronic
A
G
0.236
rs2299257
PON1
Intronic
C
A
0.391
rs854560
PON1
Coding
T
A
0.360
rs3917498
PON1
Intronic
A
C
0.345
rs28699500
PON1
Intronic
G
A
0.289
rs854561
PON1
Intronic
A
G
0.357
rs854565
PON1
Intronic
A
G
0.294
rs2272365
PON1
Intronic
C
A
0.154
rs854567
PON1
Intronic
A
G
0.185
rs3917490
PON1
Intronic
A
G
0.490
rs2299261
PON1
Intronic
G
A
0.354
rs854568
PON1
Intronic
G
A
0.219
rs2299262
PON1
Intronic
A
G
0.399
rs854569
PON1
Intronic
A
C
0.216
rs2237583
PON1
Intronic
A
G
0.284
rs3917486
PON1
Intronic
A
G
0.054
rs3917481
PON1
Intronic
A
G
0.015
rs2237584
PON1
Intronic
A
G
0.058
rs3917478
PON1
Intronic
G
A
0.118
rs3917476
PON1
Intronic
A
C
0.031
rs854571
PON1
5′-upstream
A
G
0.289
rs13236941
PON1
5′-upstream
A
G
0.164
rs13228784
PON1
Intronic
G
A
0.255
rs17883513
PON1
Intronic
G
A
0.032
rs17886762
PON1
Intronic
A
G
0.072
rs17883952
PON1
Intronic
A
G
0.052
rs17884000
PON3
Intronic
G
A
0.202
rs9640632
PON3
3′-UTR
G
A
0.456
rs468
PON3
Intronic
G
A
0.066
rs11768074
PON3
Intronic
A
G
0.157
rs10487132
PON3
Intronic
G
A
0.390
rs740264
PON3
Intronic
C
A
0.254
rs17884563
Intergenic
Intergenic
T
A
0.109
rs17880030
Intergenic
Intergenic
A
G
0.199
rs17881071
Intergenic
Intergenic
A
G
0.198
rs2375005
PON2
Intronic
T
A
0.462
rs12026
PON2
Coding
C
G
0.240
rs2299264
PON2
Intronic
A
G
0.241
rs7803148
PON2
Intronic
A
G
0.405
rs2158806
PON2
Intronic
C
A
0.237
rs2286233
PON2
Intronic
A
T
0.131
rs10259688
PON2
Intronic
G
A
0.179
rs730365
PON2
Intronic
A
G
0.132
Abbreviations: UTR = untranslated region, MAF = minor allele frequency, intergenic = located between two gene regions.
a SNP functional annotation from SNP-Nexus.
b Major and minor allele annotation from the Illumina HumanCVD Bead Chip.
c Minor allele frequencies calculated from the CLEAR study cohort.