Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

<div>(a) and (b) Effect of MDCO-216 preincubated with 4% HSA (a) or with human serum (b) on global and ABCA1-mediated cholesterol efflux from J774 macrophages. Blue: basal efflux (efflux from cells not pretreated with cAMP), red bars: ABCA1-mediated efflux (additional efflux due to pretreatment of cells with cAMP). (c) The same data of (a) giving concentration of MDCO-216 (as protein) in the incubation medium of the efflux assay, compared with efflux induced by 20 <i>μ</i>g/mL pure human wild-type apoA-I (uncomplexed) in the same run.</div>

Journal of Lipids

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Figure 1

Figure 1: Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size 

Figure 1 | Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size 