Physiological and Pathological Functions of TMEM30A: An Essential Subunit of P4-ATPase Phospholipid Flippases

Figure 2

Cryo-EM structures of P4-ATPases-TMEM30A/B complexes. ATP8A1, ATP8B1, and ATP11C share a conserved structural arrangement typical of P4-ATPases. Each has a transmembrane (TM) domain and 3 cytoplasmic domains including A (actuator), N (nucleotide-binding), and P (phosphorylation) domains. TMEM30A and TMEM30B bind P4-ATPases in largely the same conformation, without notable structural differences. PDB ID: ATP8A1-TMEM30A: 6K7M; ATP11C-TMEM30A: 6LKN; ATP8B1-TMEM30A: 7VGJ; ATP8B1-TMEM30B: 7VGH.