miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells

<div>miR-33a expression in VSMC increases ABCA1 protein without enhancing apoAI-mediated cholesterol efflux. Representative immunoblot (a) for detection of ABCA1 protein and HSP90 housekeeping protein within lysates from WT and KO MOVAS cells cultured in basal conditions and immunoblotting quantification (b) of ABCA1 protein. (c) Cholesterol efflux measured in serum-starved, [<sup>3</sup>H] cholesterol-loaded WT and KO MOVAS cells incubated with apoAI.</div>

Journal of Lipids

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Figure 2

Figure 2: miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells 

Figure 2 | miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells 