miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells

<div>miR-33a expression in MLC impairs ABCA1-dependent cholesterol efflux. Representative immunoblot (a) for detecting ABCA1 protein and HSP90 housekeeping protein in lysates of WT and KO MOVAS MLC cultured in serum-free medium containing M<i>β</i>CD:Chol and immunoblot quantification (b) of ABCA1 protein. (c) Cholesterol efflux measured in serum-starved, M<i>β</i>CD:Chol-loaded, and [<sup>3</sup>H] cholesterol-loaded WT and KO MOVAS MLC exposed to apoAI.</div>

Journal of Lipids

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Figure 4

Figure 4: miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells 

Figure 4 | miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells 