Research Article

Plasma Lipidomics Profiling to Identify the Biomarkers of Diagnosis and Radiotherapy Response for Advanced Non-Small-Cell Lung Cancer Patients

Table 2

More than twofold elevated lipid elements of NSCLC patients in pre-RT, RT, and post-RT groups with statistical significance, as compared with healthy control ( or less).

Pre-RT/ConRT/ConPost-RT/Con
ElementsFold change valueElementsFold change valueElementsFold change value

PS (20 : 0/20 : 1)2.2000.015PA (20 : 0/16 : 1)2.0900.016PG (18 : 0/16 : 1)2.2430.034
PI (20 : 0/22 : 5)2.2690.022PI (18 : 1/18 : 1)2.1200.005PS (18 : 0/16 : 1)2.335<0.001
PS (18 : 0/16 : 1)2.391<0.001PA (18 : 0/20 : 2)2.2230.003PI (18 : 0/22 : 4)2.3610.022
PS (20 : 0/18 : 1)2.395<0.001PI (16 : 0/18 : 1)2.3940.001PI (18 : 1/18 : 2)2.3710.012
LPS (16 : 0)2.4940.003PI (18 : 0/18 : 1)2.490<0.001PS (20 : 0/20 : 1)2.4530.006
LPS (18 : 0)2.5110.003PI (18 : 0/16 : 1)2.6210.003PI (18 : 0/18 : 1)2.5610.041
PS (20 : 0/16 : 1)2.541<0.001PG (18 : 1/18 : 2)2.6400.001PS (20 : 0/18 : 1)2.565<0.001
PG (16 : 0/16 : 1)2.6860.032PS (20 : 0/18 : 1)2.644<0.001PS (20 : 0/16 : 1)2.592<0.001
PG (18 : 0/16 : 1)2.7850.001PG (16 : 0/16 : 1)2.679<0.001PS (18 : 0/14 : 0)2.5970.013
PS (14 : 0/22 : 5)3.1440.002PS (20 : 0/16 : 1)2.818<0.001PG (16 : 0/16 : 1)2.6860.002
PI (18 : 0/20 : 3)3.3160.001PI (18 : 0/20 : 2)2.8550.019PG (18 : 1/18 : 2)2.778<0.001
PS (18 : 0/14 : 0)3.8210.001LPS (18 : 0)2.968<0.001PI (18 : 0/20 : 3)2.8640.006
PS (20 : 0/20 : 5)5.192<0.001PI (18 : 1/18 : 2)3.056<0.001LPS (18 : 0)2.8970.001
PI (14 : 0/18 : 1)6.047<0.001PG (18 : 0/16 : 1)3.088<0.001PI (16 : 0/18 : 1)2.9370.003
PS (18 : 0/20 : 0)15.236<0.001PA (16 : 0/18 : 1)3.6290.004PG (18 : 1/18 : 1)2.9940.001
PI (18 : 0/20 : 4)30.836<0.001PI (18 : 0/20 : 3)3.8900.001PA (16 : 0/18 : 1)4.4680.001
PS (20 : 0/20 : 5)5.264<0.001PS (20 : 0/20 : 5)5.034<0.001
PI (14 : 0/18 : 1)8.042<0.001PI (14 : 0/18 : 1)6.531<0.001
PS (18 : 0/20 : 0)14.602<0.001PS (18 : 0/20 : 0)13.548<0.001
PI(18 : 0/20 : 4)21.894<0.001PI(18 : 0/20 : 4)24.485<0.001

NSCLC: non-small-cell lung cancer; pre-RT: preradiotherapy; RT: radiotherapy; post-RT: postradiotherapy.