Plasma Lipidomics Profiling to Identify the Biomarkers of Diagnosis and Radiotherapy Response for Advanced Non-Small-Cell Lung Cancer Patients

Table 6

ROC curve analysis of NSCLC patients and healthy controls.

Bad/good response pre-RT			NSCLC pre-RT/Con
Elements	AUC	value	Elements	AUC	value
PG (18 : 0/20 : 1)	0.850	0.006	PS (18 : 0/20 : 0)	0.993	<0.001
PG (18 : 0/14 : 0)	0.825	0.004	Cholesterol	0.992	<0.001
PS (18 : 1/16 : 1)	0.796	0.002	PI (18 : 0/20 : 4)	0.969	<0.001
PG (18 : 1/18 : 3)	0.775	0.022	PI (14 : 0/18 : 1)	0.957	<0.001
PG (18 : 0/18 : 2)	0.767	0.009	MAG 22 : 5	0.956	<0.001
PS (16 : 0/18 : 2)	0.750	0.045	MAG 22 : 0	0.914	<0.001
PS (14 : 0/22 : 4)	0.746	0.015	PS (20 : 0/16 : 1)	0.874	<0.001
PS (20 : 0/20 : 3)	0.729	0.012	MAG 22 : 3	0.863	<0.001
PG (18 : 0/20 : 2)	0.729	0.021	MAG 20 : 0	0.845	<0.001
S-1-P	0.729	0.026	FFA(24 : 0)	0.839	<0.001
PI (14 : 0/22 : 4)	0.725	0.025	PS (20 : 0/20 : 5)	0.833	<0.001
27 OH cholesterol	0.725	0.043	PS (18 : 1/22 : 4)	0.830	<0.001
PA (14 : 0/20 : 4)	0.721	0.023	PS (18 : 0/18 : 0)	0.818	<0.001
PA (18 : 2/22 : 4)	0.717	0.027	PG (16 : 0/18 : 1)	0.810	<0.001
PS (16 : 0/20 : 5)	0.713	0.028	PS (18 : 0/16 : 1)	0.809	<0.001
PA (18 : 0/20 : 5)	0.713	0.046	PS (18 : 0/20 : 3)	0.806	<0.001
PS (20 : 0/16 : 1)	0.700	0.042
PI (20 : 0/22 : 5)	0.692	0.045
PA (14 : 0/20 : 3)	0.688	0.035

NSCLC: non-small-cell lung cancer; pre-RT: preradiotherapy; AUC: area under the curve.