Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method

Table 3

Formulation factor effects on product properties.

Form.	Feno : carrier (w : w)	Blending ability	Physical state	Z (nm)	PDI	(%) DS	Density (g/mL)	Carr’s index
Mixing method
F41	4 : 1	++	Liquid	334.7 ± 5.76	0.205 ± 0.023	8.70 ± 0.95	0.462 ± 0.079	22.50 ± 2.12
F43	4 : 3	+	Semisolid	364.7 ± 4.49	0.276 ± 0.041	5.85 ± 3.09	0.389 ± 0.032	25.33 ± 3.21
F45	4 : 5	−	Solid	302.5 ± 4.66	0.161 ± 0.002	3.97 ± 052	0.318 ± 0.063	29.00 ± 3.46
F41-CT1	4 : 1	+	Liquid	415.7 ± 4.14	0.280 ± 0.045	6.55 ± 1.41	0.477 ± 0.061	21.67 ± 2.01
F41-CT2	4 : 1	+	Liquid	381.7 ± 4.2	0.270 ± 0.025	37.43 ± 5.70	0.582 ± 0.035	19.00 ± 1.41
F41-CT3	4 : 1	−	Semisolid	268.7 ± 6.512	0.281 ± 0.029	55.86 ± 15.27	0.582 ± 0.025	21.33 ± 1.41
Granulation method
P33	3 : 3	+	Solid	454.1 ± 23.29	0.178 ± 0.06	4.01 ± 0.66	0.473 ± 0.025	24.50 ± 3.54
P38	3 : 8	+	Solid	460.0 ± 22.89	0.172 ± 0.07	7.30 ± 2.96	0.314 ± 0.023	33.00 ± 5.19
P315	3 : 15	+	Solid	559.4 ± 46.56	0.174 ± 0.12	10.23 ± 0.23	0.250 ± 0.029	37.00 ± 1.41
P38-CT3	3 : 8	+	Solid	454.1 ± 4.188	0.254 ± 0.006	9.92 ± 2.01	0.701 ± 0.059	22.19 ± 0.92
P38-CT4	3 : 8	−	Solid	–	–	4.53 ± 1.98	0.718 ± 0.032	23.16 ± 0.04

Z, particle size; PDI, polydispersity index; %DS, percentage of the drug in the supernatant.