Review Article

Recent Applications and Evaluation of Metal Nanoparticle–Polymer Hybrids as Chronic Wound Dressings

Table 1

The characteristics and applications of different nanoparticle loaded hydrogel nanocomposite are discussed.

Biopolymers/synthetic polymersNanoparticlesPropertiesApplicationsReferences

Gelatin–methycryloyl (GelMA)CeO2 (CONPs)Antioxidant, biodegradable, in vitro cell proliferation, high exudate absorption capacity, and increased porosityDiabetic wound healing hydrogel patch[141]
Gelatin–dextran (Gel/Dex)Curcumin (CUR) and CeO2 (CONPs)Antioxidant and anti-inflammatory activities, rapid cell migration, biodegradable, and biocompatibleInflammation-based pathology wound healing hydrogel[86]
Acrylamide–gelatin (Gel-AM)AgNPsAntibacterial against Gram +, biodegradable, and higher water intake capacityWound and burn treatment hydrogel[151]
Gelatin–methycryloyl (GelMA)AgNPsAntibacterial against Gram + and Gram −, nontoxic to cells, rapid fibroblast migration, and biodegradableDeep dermal wound healing hydrogel[153]
Gelatin–chitosan (CS–Gel)AuNPsAntibacterial against Gram +, biocompatible, high porosity, and effective water absorption capacityMAR bacteria infected wound healing hydrogel[102]
Bacterial cellulose (BC)AgNPsAntibacterial against Gram −General and surgical wound healing dressing material[154]
Carboxymethyl–cellulose (CMC)CuONPsAntibacterial against Gram + and Gram −Different biomedical applications[156]
Carboxymethyl cellulose–layered double hydroxide (CMC–LDH)AgNPsAntibacterial against Gram + and Gram −Different biomedical applications[156]
Chitosan (CS)AgNPs and AuNPsAntibacterial against Gram + and Gram −, nontoxic, high porosity, excellent mechanical properties, good swelling and retention property, and easily removableWound dressing material[158]
Chitosan–polyvinyl alcohol (PVA–CS)CeO2 (CONPs)Antibacterial against Gram +, nontoxic, excellent water absorption capacity, enhanced porosity, and good swelling propertiesWound dressing material[85]
Chitosan (CS)CuONPsAntibacterial against Gram + and Gram −Various biomedical applications[161]
Chitosan–polyvinyl alcohol/heparin (PVA–CS/Hep)ZnO (ZONPs)Antibacterial against Gram + and Gram −, excellent mechanical strength, high water vapor permeability, and good swelling propertiesWound dressing material[163]