Obesity, broadly defined by body mass index or total body fat, is associated with greater risk for cardiometabolic disease. However, it is becoming increasingly recognized that body mass index and total body fat do not accurately reflect metabolic risk. Rather, the anatomical location of excess fat appears to be more important. In recent years, and following the advances in imaging techniques, many studies have demonstrated that accumulation of fat in the liver is strongly associated with metabolic dysfunction, that is, multiorgan insulin resistance and dyslipidemia, possibly more so than visceral adiposity or intramyocellular lipid accumulation. Intrahepatic fat, which only modestly correlates with body mass index, may thus be a prominent factor modifying the metabolic risk associated with increasing whole-body adiposity. Even though cause-and-effect relationships have yet to be established, understanding of the regulation of fat accumulation in the liver will have important implications in both research and clinical practice. Little, however, is known regarding the specific effects of lifestyle factors such as diet and exercise in regulating the accumulation of fat in the liver and its depletion thereof.

We invite investigators to contribute original research in humans and animals and also review articles that will promote our understanding of the regulation of liver fat stores by diet and exercise. We are particularly interested in studies in humans, of any health status (e.g., healthy subjects or patients with obesity or insulin resistance, diabetes, or nonalcoholic fatty liver disease) and age and especially both sexes, examining the effects of specific dietary components or exercise modalities, and also animal studies describing relevant cellular and molecular mechanisms. Potential topics include, but are not limited to:

• Effects of caloric restriction, with particular focus on the importance of different macronutrient content
• Effects of variation in macronutrient intake under isocaloric feeding
• Effects of micronutrient supplementation
• Effects of acute and chronic aerobic and resistance exercise and also physical inactivity including bed rest and detraining
• Effects of multifactorial lifestyle interventions
• Sex differences in response to diet and exercise
• Studies elucidating the cellular and molecular mechanisms involved in the effects of diet and exercise

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jnume/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: