Preeclampsia: Molecular Mechanisms, Predisposition, and Treatment
1Department of Obstetrics and Gynecology, University of Athens, 115 28 Athens, Greece
2Department of Gynaecological Oncology, Obstetrics & Gynaecology, Queen Charlotte's & Chelsea, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
Preeclampsia: Molecular Mechanisms, Predisposition, and Treatment
Description
Preeclampsia is a severe pregnancy-specific disorder. The mechanisms responsible for the pathogenesis of preeclampsia have not yet been clearly identified. The most well-accepted hypothesis for the pathogenesis of the disease is that placental ischemia/hypoxia results from inadequate cytotrophoblast invasion of the uterine spiral arteries, which leads to a decrease in uteroplacental blood flow. Subsequently, factors are released from the ischemic placenta. Recent advances in biology and medicine have introduced new technologies to study the genetics of preeclampsia and the mechanisms underlying its pathology. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize this clinical condition and provide better care to patients.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying preeclampsia, the development of strategies to treat this condition, and the evaluation of outcomes.
We are particularly interested in articles describing the new modalities for clinical characterization of preeclampsia and measuring outcomes from treatment trials, advances in molecular genetics and molecular diagnostics, new insights into preeclampsia predisposition, exploration of preeclampsia by using animal models and current concepts in the treatment strategies of preeclampsia. Potential topics include, but are not limited to:
- Recent developments in preeclampsia predisposition disease research
- Advances in genetics of preeclampsia
- Latest technologies for clinical evaluation and measuring outcomes
- Role of inflammation in preeclampsia
- Role of ischemia in preeclampsia
- Preeclampsia mechanism using model systems
- Noninvasive prenatal diagnosis of preeclampsia
- Pharmacogenomics in preeclampsia
- Short- and long-term strategies for the management of preeclampsia
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