The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels

Table 6

Regression analyses of initial ados subscales versus urinary metal excretion and initial glutathione. In the regression equation, the suffixes for the metals refer to the value at Baseline (B) and after the 9th ( 9) dose of DMSA in Phase 1.

	Adjusted 𝑅^2	𝑃-value	Equation	Most significant variables
ADOS-Sociability	0.41	0.004	8.70 +1.20 PbB + 0.217 SnB + 12.7 TlB − 1.64 HgB − 10.2 SbB − 2.61 CdB − 0.631 AlB − 0.186 Pb9 − 7.13 Tl9 + 6.27 Sb9 +6.15 W9 +3.62 Cd9	W9∗∗∗, AlB∗∗, TlB∗, HgB∗, Pb9∗, Tl9∗
ADOS-Commun.	0.37	0.0003	2.39–2.57 HgB + 23.1 SbB + 2.32 Hg9 + .0048 Glut	HgB∗∗, Hg9∗∗, SbB∗∗
ADOS-Play	0.24	0.004	1.20 + 0.540 PbB + 4.23 Sb9 + 0.0017 Glut	PbB∗
ADOS-SBRI	0.21	0.02	4.64–0.897 HgB − 2.63 CdB − 0.26 AlB + 0.050 Pb9 + 0.730 Hg9

^∗∗∗𝑃<.001, ^∗∗𝑃<.01, ^∗𝑃<.05