Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection

Figure 3

The levels of IL-4, IL-10, IL-12 p70, and IFN-γ cytokines in HEV-recovered and control groups following stimulation with the truncated ORF2 protein. Significant amounts of IFN-γ and IL-12 cytokines but low amounts of IL-10 and IL-4 cytokines were produced. IL-12 p70 and IFN-γ cytokines production following stimulation with the truncated ORF2 protein was significantly higher in the recovered group compared to the control group, while there were no significant differences in the levels of IL-10 and IL-4 between the two groups. Both groups showed almost similar expression of all cytokines following stimulation with PHA. Results are shown as mean ± SD pg/mL.