Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection

Table 1

Results of cytokine, lymphocyte proliferation, and ELISPOT assays in response to truncated ORF2 protein in HEV recovered individuals and control group.

Parameter	Control group ()	Recovered group ()	value
IFN-γ	17.12 ± 6.93	143.40 ± 52.33	<0.001
IL-12	18.33 ± 9.04	112.75 ± 43.26	<0.001
IL-10	18.72 ± 8.55	27.80 ± 19.55	0.100 (NS)
IL-4	4.30 ± 1.53	4.90 ± 1.49	0.067 (NS)
ELISPOT	4.39 ± 5.51	65.92 ± 58.99	<0.001
Cell proliferation	1.50 ± 0.17	2.01 ± 0.28	<0.001

Cytokine values are represented as picograms per milliliter (pg/mL), the results of ELISPOT assay are expressed as spot forming cells per 10⁵ cells (SFC/10⁵ cells), and the results of cell proliferation assay are shown as proliferation index (PI).
All data are shown as mean ± SD.
NS = nonsignificant.