Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice

Figure 2

Protective effect of aqueous crude extract of neem leaves on renal injury induced by Plasmodium berghei infection in mice. Groups of ICR mice (5 mice of each) were infected with 1 × 10⁷ parasitized erythrocytes of PbANKA by IP injection and given 500, 1,000, and 2,000 mg/kg of neem leaf extracts orally for 4 consecutive days. On day 5 of experiment, (a) BUN and (b) creatinine levels were measured and compared to normal and untreated groups. Results were expressed as mean ± SEM. , compared to normal group, and , compared to untreated group. N: normal mice, NE: normal mice treated with 2,000 mg/kg of neem leaf extract, and UN: untreated mice.

(a)

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