Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism
Figure 3
Effect of adenosine (ADO) on glomerular hemodynamics in normal and (NL) and hypothyroid (HTX) rats. (a) The balance of glomerular blood flow (GBF), the afferent and efferent resistances (AR, ER, resp.), and the permeability of the glomerular capillary membrane (Kf) maintain a normal glomerular filtration rate (GFR). (c) Administration of exogenous adenosine to normal rats produces an increase in afferent and efferent resistances, which in turn result in decreased glomerular blood flow and glomerular permeability; as a final consequence, the glomerular filtration rate diminishes. (b) Glomerular hemodynamics of the hypothyroid kidney. There is a glomerular vasoconstriction due to an increase in afferent and efferent resistances, a decrease in glomerular blood flow, and permeability of the glomerular capillary membrane, which results in a decreased glomerular filtration rate. (d) When exogenous adenosine is administrated to HTX rats, glomerular hemodynamics and GFR reach values near to normal. White arrows are indicative of magnitude of AR or ER, whereas yellow arrows represent the magnitude of the glomerular filtration rate.
