Journal of Thyroid Research / 2011 / Article / Tab 1 / Review Article
Role of Estrogen in Thyroid Function and Growth Regulation Table 1 Estrogen receptor (ER) in human normal thyroid, and benign and malignant thyroid diseases.
Study Method Normal All benign lesions All neoplastic lesions All carcinoma Benign lesions Carcinoma Adenoma Goiter Papillary Follicular Medullary Anaplastic Tavangar et al. [10 ]; 2007 IHC 8/37 31/130 37/119 2/18 0/35 0/12 Arain et al. [11 ]; 2003 IHC 0/25 0/9 0/8 0/19 0/10 0/4 Lewy-Trenda et al. [12 ]; 1998 IHC 2/19 0/20 4/8 3/5 0/4 Valle et al. [13 ]; 1998 RT-PCR 28/33 12/12 6/7 26/26 1/1 1/1 1/1 Bonacci et al. [14 ]; 1996 DCC 26/38 11/28 7/20 Jaklic et al. [15 ]; 1995 IHC 0/1 0/5 0/4 0/1 Colomer et al. [16 ]; 1996 IHC 1/7 Inoue et al. [17 ]; 1993 IHC 24/74 Inoue et al. [18 ]; 1993 IHC 18/70 Yane et al. [19 ]; 1994 RT-PCR 5/27 Yane et al. [20 ]; 1993 IHC 0/10 2/19 2/12 0/7 Hiasa et al. [21 ]; 1993 IHC 44/130 23/39 19/115 7/23 0/6 Diaz et al. [22 ]; 1991 IHC 20/30 23/30 11/20 Mizukami et al. [23 ]; 1991 IHC 8/18 4/8 47/62 Takeichi et al. [24 ]; 1991 IHC 11/12 1/6 Hong et al. [25 ]; 1991 IHC 1/27 1/20 Miki et al. [26 ]; 1990 DCC 0/14 12/46 7/23 5/11 2/12 6/20 0/1 1/1 Haruta et al. [27 ]; 1990 IHC 30/52 0/12 Chaudhuri et al. [28 ]; 1989 SDG 3/8 7/9 5/23 8/8 0/6 Money et al. [29 ]; 1989 IHC 20/22 Clark et al. [30 ]; 1985 SDG 14/15 Hampl [15 ]; 1985 RBA 0/8 0/5 Molteni et al. [37 ]; 1981 SDG 0/2 2/4
Data are shown as number of ER-positive samples/total number of samples. IHC: immunohistochemical assay; DCC: dextran-coated charcoal assay; RT-PCR: reverse transcriptase-polymerase chain reaction technique; SDG: sucrose density gradient assay; RBA: radioligand binding assay.