Review Article
Microchimerism in Graves' Disease
Table 1
Summary of the main experimental and clinical findings of Graves' disease and microchimerism.
| Thyroid tissue origin | Storage | N | Gene and technique | Presence of microchimeric cells (%) | Reference |
| Graves' disease | Paraffin-embedded | 20 | SRY gene by ELISA-PCR | 20% |
Ando et al. [11] | Frozen | 7 | SRY gene by ELISA-PCR | 86% |
Ando et al. [11] | Paraffin-embedded | 15 | X and Y chromosomes by FISH | 40% |
Renné et al. [14] |
| Thyroid adenoma | Paraffin-embedded | 6 | SRY gene by ELISA-PCR | 0% |
Ando et al. [11] | Frozen | 4 | SRY gene by ELISA-PCR | 25% |
Ando et al. [11] | Paraffin-embedded | 9 | X and Y chromosomes by FISH | 22% |
Renné et al. [14] |
| Hashimoto’s thyroiditis | Paraffin-embedded | 25 | X and Y chromosomes by FISH | 60% |
Renné et al. [14] |
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SRY: sex-determining region Y; PCR: polymerase chain reaction; FISH: fluorescence in situ hybridization.
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