Research Article
FoxP3-Positive T-Regulatory Cells in Lymph Nodes with Mycosis Fungoides and Sézary Syndrome
Table 5
Clinical features and pertinent laboratory findings in the study patients.
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Status at time of lymph node biopsy. TNMB ratings according to Olsen et al. [3]. Lower case “x” signifies missing molecular analysis for T-cell clonality. †Maximum lymph node size based on clinical assessment or CT scan (not necessarily biopsied). ‡Evidence of large-cell transformation. Lymph node grading according to NCI-MFCG criteria [23]. LN0-2 and LN4 used to define DL and CTCL, respectively. #All specimens studied for T cell receptor gamma gene rearrangment by polymerase chain reaction followed by denaturing gradient electrophoresis except for patients 2 and 19 (PCR-single strand conformational electrophoresis), patients 9, 10 and 21 (PCR-fluorophore labeled primer with capillary gel electrophoresis) and patient 22 (Southern blot technique). Abbreviations: Pt: patient number; ClinDx: clinical assessment; TNMB: tumor-node-metastasis-blood; LN: lymph node; MG: T cell clonality by molecular testing; CTCL: cutaneous T cell lymphoma; MF: mycosis fungoides, patch (PT), plaque (PQ), tumor (T) phases; MF-E: erythroderma preceded by MF; NOS: not otherwise specified; SS: Sézary syndrome; PathDx: histological assessment; DL: dermatopathic lymphadenitis. |