Review Article

Priming DNA Replication from Triple Helix Oligonucleotides: Possible Threestranded DNA in DNA Polymerases

Figure 1

Model for the slippage mispairing between direct repeats. (1) Synthesized purine-rich DR1 sequence the [DNA polymerase-neosynthesized DNA complex] would dissociate from its template and bind to the homologous duplex sequence. (2) The triple helix bound to the duplex DNA is in a parallel orientation as the homologous strand and primes DNA replication on DR2. (3) Elongation of the THP on the DS DNA by DNA polymerase.
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