Research Article
A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis
Table 2
Genotyping and allele frequency of ORAI1 gene in rheumatoid arthritis patients and normal controls.
| | | Genotype | Case (%)
() | Control subjects (%)
() | Allele | Case (%)
() | Control subjects
(%) () | Genotype
value | Recessive
value | Allelic
value |
| | rs12320939 | TT | 95 (24.4) | 144 (23.4) | T | 382 (49.1) | 602 (48.9) |
0.868 | 0.715 | 0.945 | | TG | 192 (49.4) | 314 (51.1) | G | 396 (50.9) | 628 (51.1) | 1.06 | 1.01 | | GG | 102 (26.2) | 157 (25.5) | | | | (0.79–1.42) | (0.84–1.20) |
| | rs12313273 | CC | 28 (7.8) | 54 (8.8) | C | 202 (28.0) | 355 (28.9) |
0.850 | 0.573 | 0.660 | | CT | 146 (40.4) | 247 (40.2) | T | 520 (72.0) | 873 (71.1) | 0.87 | 0.96 | | TT | 187 (51.8) | 313 (51.0) | | | | (0.54–1.40) | (0.78–1.17) |
| | rs7135617 | TT | 83 (22.5) | 96 (15.5) | T | 318 (43.1) | 505 (40.9) | 0.004* | 0.006* | 0.331 | | TG | 152 (41.2) | 313 (50.7) | G | 420 (40.9) | 731 (59.1) | 1.58 | 1.10 | | GG | 134 (36.3) | 209 (33.8) | | | | (1.14–2.19) | (0.91–1.32) |
| | rs6486795 | CC | 57 (14.9) | 82 (13.3) | C | 291 (38.1) | 464 (37.7) |
0.687 | 0.475 | 0.849 | | CT | 177 (46.3) | 300 (48.7) | T | 473 (61.9) | 768 (62.3) | 1.14 | 1.02 | | TT | 148 (38.7) | 234 (38.0) | | | | (0.79–1.65) | (0.85–1.23) |
| | rs712853 | CC | 37 (9.7) | 64 (10.6) | C | 238 (31.1) | 396 (32.7) |
0.740 | 0.643 | 0.442 | | CT | 164 (42.8) | 268 (44.3) | T | 528 (68.9) | 814 (67.3) | 0.90 | 0.93 | | TT | 182 (47.5) | 273 (45.1) | | | | (1.38–0.59) | (1.13–0.76) |
|
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Significant () values are in bold.
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