Review Article
Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development
Table 3
Associations between MPNs and cytokines.
| Inflammatory marker | Impact | Disorder |
| B2MICG | Symptoms | MF | BMP1 | Disease advancement | PMF | BMP6 | Disease advancement | PMF | BMP7 | Disease advancement | PMF | BMP-Rcp2 | Disease advancement | PMF | CD40L | Loss of appetite | MF | CRP | Thrombosis; atherogenesis | PV, ET | Ferritin | Pruritus | MF | FGF | Marrow fibrosis | PV, ET, PMF | HGF | Splenomegaly | PMF | IFN | Associated with JAK2V617F | MF | IL-12 | Inferior survival; transfusion requirements, vascular complications | MF | IL-15 | Inferior survival | MF | IL-17A | Associated with JAK2V617F | MF | IL-1B | Associated with JAK2V617F | MF | IL-1RA | Splenomegaly | PMF | IL-2R | Inferior survival; transfusion requirements | MF | IL-8 | Elevated blasts; constitutional symptoms | MF | IL-8 | Associated with JAK2V617F | MF | IP-10 | Inferior survival | MF | LEPTIN | Symptoms; weight loss | MF | MIG | Splenomegaly | PMF | PAL1 | Insomnia | MF | PTX | Thrombosis; atherogenesis | PV, ET | RANTES | Insomnia | MF | TIMP1 | Symptoms | MF | TNF-1 | Clonal expansion | JAK2V617F+ MPNs | TNFRII | Symptoms | MF | VCAM1 | Symptoms | MF | VEGFb | Marrow fibrosis | PV, ET, PMF |
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ET: essential thrombocythemia; MF: myelofibrosis; MPN: myeloproliferative neoplasm; PMF: primary myelofibrosis; PV: primary myelofibrosis. Refer to Table 2 for definition.
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